Tetrahydrofuran → N-acetyl-N1-[4-(4-ethyl-2-hydroxyphenoxy)-3-fluorophenyl]propan-1,3-diamine

HRID 626073ノート

反応式

HRID 626073 の反応式
[C:1]([N:4]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH3:23])=[CH:18][C:17]=2[O:24]CC2C=CC=CC=2)=[C:11]([F:32])[CH:10]=1)[CH2:5][CH2:6][CH2:7][NH2:8])(=[O:3])[CH3:2].O1CCCC1>CO>[C:1]([N:4]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH3:23])=[CH:18][C:17]=2[OH:24])=[C:11]([F:32])[CH:10]=1)[CH2:5][CH2:6][CH2:7][NH2:8])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 8028TetrahydrofuranHCID 68547880N-acetyl-N1-[4-(2-Benzyloxy-4-ethylphenoxy)-3-fluorophenyl]propan-1,3-diamine

生成物 1

HCID 68549004N-acetyl-N1-[4-(4-ethyl-2-hydroxyphenoxy)-3-fluorophenyl]propan-1,3-diamine収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

According to the procedure of example 20 (b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl) phenoxy]benzene for N-acetyl-N1-[4-(2-Benzyloxy-4-ethylphenoxy)-3-fluorophenyl]propan-1,3-diamine (70 mg, 0.16 mmol) and tetrahydrofurane for methanol (15 mL), the title compound (50 mg, 91%) was obtained as a brown liquid, after purification on silica gel (dichloromethane/ethyl acetate: 5/5)

出典と根拠

ORDレコード
ord-8cbc1f9454ff44e4aeb5207f40b0b7d7
出典データセット
uspto-grants-2016_04
特許番号
US09309179B2

反応ノート

読み込み中…