Nitric Acid → N-(2-nitro-4-propanoylphenyl)acetamide
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].[N+:15]([O-])([OH:17])=[O:16].O>OS(O)(=O)=O>[N+:15]([C:7]1[CH:6]=[C:5]([C:1](=[O:4])[CH2:2][CH3:3])[CH:10]=[CH:9][C:8]=1[NH:11][C:12](=[O:14])[CH3:13])([O-:17])=[O:16]参加物
5
反応条件
- 温度
- -10 °C
実験手順
To a solution of N-(4-propionylphenyl)acetamide (1.91 g, 10 mmol) in 20 mL of concentrated H2SO4 was added 2 mL 98% HNO3 over 10 minutes while maintain the temperature at −10° C. After stirring for 0.5 h, the mixture was poured into 100 mL of cold water. The precipitate was collected by filtration and washed with water to give the crude product (1.18 g, 50%), which was used directly in the next step.
後処理
- filtrationThe precipitate was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-a2b8cf2a46fe4d2d8ecb911e4e67f785
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309211B2
反応ノート
読み込み中…