1-Phenylpropan-1-amine → HCID 178457662、化合物

HRID 626391

反応式

HRID 626391 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[NH:3][CH:2]=1.CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:46]([CH:48]([NH2:55])[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)[CH3:47]>CN(C=O)C>[C:49]1([CH:48]([NH:55][C:10]([C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[O:12])[CH2:46][CH3:47])[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1

参加物

6

反応物 4

HCID 180541-Phenylpropan-1-amineHCID 81531DiisopropylethylamineHCID 4594565-Benzimidazolecarboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

生成物 1

HCID 178457662HCID 178457662、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 5-benzimidazole-carboxylic acid in DMF was added DIPEA (1.3 equiv) and HATU (1.2 equiv). The mixture was stirred for 5 min, and then α-ethylbenzylamine (1.1 equiv) was added. The reaction mixture was stirred at rt. for 1 h. After the reaction was completed, the solvent was removed in vacuo to obtain the crude which was purified by flash chromatography to obtain the title compound. LC-MS 280 (M+H).

後処理

  1. stirringThe reaction mixture was stirred at rt
  2. waitfor 1 h
  3. customthe solvent was removed in vacuo
  4. customto obtain the crude which
  5. customwas purified by flash chromatography

出典と根拠

ORDレコード
ord-361e8ee80b2f4d82aaeba12735cad980
出典データセット
uspto-grants-2016_04
特許番号
US09309227B2

関連ノート

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