Thionyl Chloride → 3,5-Difluoropyridine-2-carbonyl chloride
反応式
[F:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([C:9]([Cl:14])=[O:11])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1参加物
3
実験手順
A suspension of 5.00 g (31.4 mmol) of 3,5-difluoropyridine-2-carboxylic acid in thionyl chloride (21 ml) was heated to reflux for 5 h. The solution was concentrated, and the residue was twice taken up in a little toluene and concentrated again. This gave 3.80 g of a solid, which was reacted further directly without further purification.
後処理
- temperaturewas heated
- temperatureto reflux for 5 h
- concentrationThe solution was concentrated
- concentrationconcentrated again
- customThis gave 3.80 g of a solid, which was reacted further directly without further purification
出典と根拠
- ORDレコード
- ord-8fd59b65374c4ddc91cf159513eccf6c
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309239B2
反応ノート
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