tert-Butyl 2-nitro-4-(thiophen-2-yl)phenylcarbamate → tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate

HRID 62666

反応式

[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:6][C:5]=1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])([O-])=O>C(O)C.CO.[Pd]>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:6][C:5]=1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21]

参加物

実験手順

To a solution of tert-butyl (2-nitro-4-(thiophen-2-yl)phenyl)carbamate (2 g, 6.2 mmol, 1.0 eq.) in ethanol (20 mL) and methanol (20 mL) was added 10% Pd/C (0.66 g, 0.1 eq.). The reaction mixture was stirred 12 h under a hydrogen atmosphere. The reaction was filtered and the filtrate was concentrated under reduced pressure to give tert-butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate (1.25 g, 69% yield) as an off-white solid.

後処理

filtrationThe reaction was filtered
concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-1d4ead8e26a1418982cbebc4494fe31e
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447030B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 3

実験手順

後処理

出典と根拠

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