Ammonia → 2-(2,6-Dichlorophenyl)-2h-pyrazolo[4,3-c]pyridin-4-amine

HRID 626665

反応式

HRID 626665 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[CH:26]=[C:12]2[C:13]([NH:17]C3C=C(NC)N=CN=3)=[N:14][CH:15]=[CH:16][C:11]2=[N:10]1.ClC1C2=CN(C3C(Cl)=CC=CC=3Cl)N=C2C=CN=1.N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[CH:26]=[C:12]2[C:13]([NH2:17])=[N:14][CH:15]=[CH:16][C:11]2=[N:10]1

参加物

4

反応物 3

HCID 222AmmoniaHCID 69671122N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N'-methylpyrimidine-4,6-diamineHCID 866970364-chloro-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine

生成物 1

HCID 696711782-(2,6-Dichlorophenyl)-2h-pyrazolo[4,3-c]pyridin-4-amine収率 53%

実験手順

Following the procedure described for N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N′-methylpyrimidine-4,6-diamine, 4-chloro-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine and 33% aqueous ammonia (1.5 mL) were reacted to afford the title compound as a white solid (139 mg, 53% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.66 (d, J=0.9 Hz, 1H), 7.79-7.77 (m, 2H), 7.67 (dd, J=9.0, 7.3 Hz, 1H), 7.58 (d, J=6.5 Hz, 1H), 7.10 (br s, 2H), 6.74 (dd, J=6.5, 1.0 Hz, 1H). LCMS (Method B): RT=2.54 min, m/z: 279 [M+H+].

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-3416609ea71045369be752c1380bf9a6
出典データセット
uspto-grants-2016_04
特許番号
US09309240B2

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