Sodium Azide → 4-Azido-5-bromo-pyridine-3-carbaldehyde

反応式

[N:1]([C:4]1[C:9](Cl)=[CH:8][N:7]=[CH:6][C:5]=1[CH:11]=[O:12])=[N+:2]=[N-:3].[Br:13]C1C(Cl)=C(C=O)C=NC=1.[N-]=[N+]=[N-].[Na+]>>[N:1]([C:4]1[C:9]([Br:13])=[CH:8][N:7]=[CH:6][C:5]=1[CH:11]=[O:12])=[N+:2]=[N-:3]

参加物

反応物 3

HCID 33557Sodium Azide

HCID 717423075-Bromo-4-chloropyridine-3-carbaldehyde

HCID 866970494-Azido-5-chloropyridine-3-carbaldehyde

生成物 1

HCID 866970574-Azido-5-bromo-pyridine-3-carbaldehyde収率 83%

実験手順

Following the procedure described for 4-azido-5-chloro-pyridine-3-carbaldehyde, 5-bromo-4-chloropyridine-3-carbaldehyde and sodium azide were reacted to afford the title compound as a pale yellow solid (3.18 g, 83% yield). 1H NMR (400 MHz, CDCl3): δ 10.30 (s, 1H), 8.85 (s, 1H), 8.79 (s, 1H).

後処理

customwere reacted

出典と根拠

ORDレコード: ord-ebc86967ac0a4a35accf5e09416a2f42
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09309240B2

反応ノート

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