HCID 53420017、化合物 → Tert-butyl 4-amino-2-methoxybenzoate
反応式
[CH3:1][O:2][C:3]1[CH:15]=[C:14]([N+:16]([O-])=O)[CH:13]=[CH:12][C:4]=1[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6]>CO.[Pd]>[NH2:16][C:14]1[CH:13]=[CH:12][C:4]([C:5]([O:7][C:8]([CH3:10])([CH3:11])[CH3:9])=[O:6])=[C:3]([O:2][CH3:1])[CH:15]=1参加物
4
実験手順
tert-Butyl 2-methoxy-4-nitrobenzoate (2) (271 mg, 1.07 mmol) was dissolved in MeOH (270 mL) and passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 25° C. under full H2 mode. The solvent was removed in vacuo to afford tert-butyl 4-amino-2-methoxybenzoate (3) (234 mg, 92%) as a pale yellow solid: m/z 222 [M−H]− (ES−); 1H-NMR (400 MHz, DMSO-d6) δ: 7.41 (1H, d), 6.16 (1H, d), 6.09 (1H, dd), 5.82 (2H, br s), 3.68 (3H, s), 1.45 (9H, s).
後処理
- customat 25° C.
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-e1cec93805c948b6bc8289e6761533fe
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447028B2
反応ノート
読み込み中…