Thionyl Chloride → 2-Fluoropyridine-5-carbonyl chloride
反応式
[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:13])=O>>[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([Cl:13])=[O:10])=[CH:4][CH:3]=1参加物
3
反応条件
- 温度
- 80 °C
実験手順
In a 100-mL round-bottom flask was placed a solution of 6-fluoropyridine-3-carboxylic acid (5.0 g, 35.4 mmol) in thionyl chloride (20 mL). The resulting solution was heated at 80° C. for 2 hours and concentrated under vacuum to give the title compound as a yellow oil.
後処理
- customIn a 100-mL round-bottom flask was placed
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-7ebacbd88c974eeaa7baa374f072bab9
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309222B2
反応ノート
読み込み中…