関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-5-bromobenzoic acid | HCID 79858 | — |
| 反応物 | 1,1,1-Trifluoro-3-phenyl-2-propanone | HCID 222958 | — |
| 反応物 | Phosphorus Pentoxide-Methanesulfonic Acid | HCID 86584057 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178515323 | HCID 178515323 | — |
反応手順
A mixture of 2-amino-5-bromobenzoic acid (3.01 g, 13.9 mmol), 1,1,1-trifluoro-3-phenylpropan-2-one (3.11 g, 16.5 mmol), and Eaton's reagent (9.3 mL) in a sealed tube was heated at 100° C. for 4 hours. The reaction mixture was then allowed to cool to room temperature, water was added slowly, and the mixture was stirred vigorously for about 15 min. The precipitated solid was filtered, washed with water, and dried to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09309222B2 |
|---|
| 出典データセット | uspto-grants-2016_04 |
|---|
| ORD ID | ord-bc9ca85abd7b4788aa124e5e9ac7b94a |
|---|
| 出典メモ | uspto-grants-2016_04 |
|---|
