Hydrochloric Acid → 4-Chloro-3,5-diisopropoxybenzoic acid

HRID 62751ノート

反応式

HRID 62751 の反応式
[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:15])[CH3:14])=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18].[OH-].[Na+].Cl>>[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:14])[CH3:15])=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67041833Methyl 4-chloro-3,5-diisopropoxybenzoate

生成物 1

HCID 670418114-Chloro-3,5-diisopropoxybenzoic acid収率 68.8%

反応条件

温度
100 °C

実験手順

Methyl 4-chloro-3,5-diisopropoxybenzoate (5) (93 mg, 0.32 mmol) was suspended in 2M sodium hydroxide (1.6 mL, 3.2 mmol) and stirred at 100° C. for 3 h. After cooling to RT the mixture was acidified by the addition of 1 M HCl. The resulting precipitate was collected by filtration and dried in vacuo to afford 4-chloro-3,5-diisopropoxybenzoic acid (6) (60 mg, 66% yield) as a white solid. This material was used in the subsequent reaction step without purification.

後処理

  1. temperatureAfter cooling to RT the mixture
  2. filtrationThe resulting precipitate was collected by filtration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-9c3a79757fb14569bc674a86fcea72ca
出典データセット
uspto-grants-2016_09
特許番号
US09447028B2

反応ノート

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