2-Amino-5-chloropyridine → methyl 3-(5-chloro-2-iminopyridin-1(2H)-yl)-2-oxobutanoate hydrobromide

HRID 627697ノート

反応式

HRID 627697 の反応式
[Br:1][CH:2]([CH3:9])[C:3](=[O:8])[C:4]([O:6][CH3:7])=[O:5].[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][N:12]=1>COCCOC>[BrH:1].[Cl:17][C:14]1[CH:15]=[CH:16][C:11](=[NH:10])[N:12]([CH:2]([CH3:9])[C:3](=[O:8])[C:4]([O:6][CH3:7])=[O:5])[CH:13]=1

参加物

4

反応物 2

HCID 661742-Amino-5-chloropyridineHCID 11183175Methyl 3-bromo-2-oxobutanoate

生成物 1

HCID 86728148methyl 3-(5-chloro-2-iminopyridin-1(2H)-yl)-2-oxobutanoate hydrobromide収率 62%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

To a solution of methyl 3-bromo-2-oxobutanoate (8.26 g, 42.4 mmol) in DME (33 mL) at room temperature was added 2-amino-5-chloropyridine (5.45 g, 42.4 mmol). The reaction mixture was stirred at room temperature for 20 h. The solid was collected by filtration, washed with EtOAc (2×), and dried under high vacuum to give methyl 3-(5-chloro-2-iminopyridin-1(2H)-yl)-2-oxobutanoate hydrobromide (8.51 g, 26.3 mmol, 62% yield) as a white solid.

後処理

  1. filtrationThe solid was collected by filtration
  2. washwashed with EtOAc (2×)
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-c20f4f2d535545609f935574bdec11e5
出典データセット
uspto-grants-2016_04
特許番号
US09309263B2

反応ノート

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