Trifluoroacetic acid → HCID 178511296、化合物

HRID 628357ノート

反応式

HRID 628357 の反応式
[C:1]([C@H:3]1[CH2:6][C@H:5]([NH:7]C(=O)OC(C)(C)C)[CH2:4]1)#[N:2].[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16].[NH2:7][C@H:5]1[CH2:6][C@H:3]([C:1]#[N:2])[CH2:4]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178454087HCID 178454087、化合物

生成物 1

HCID 178511296HCID 178511296、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-Butyl (trans-3-cyanocyclobutyl)carbamate (0.061 g, 0.31 mmol) was stirred with TFA (2 mL) in DCM (4 mL) for 1 hour. The solvents were removed in vacuo and the residue was reconstituted in DCM and subjected to rotary evaporation an additional 2 times to rid of excess TFA in the product, which was used without further purification in Step 5.

後処理

  1. customThe solvents were removed in vacuo
  2. customsubjected to rotary evaporation an additional 2 times
  3. customwas used without further purification in Step 5

出典と根拠

ORDレコード
ord-f07d0eb518f742c2895ae1c18e1f6d79
出典データセット
uspto-grants-2016_04
特許番号
US09309246B2

反応ノート

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