(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

HRID 62836

反応式

HRID 62836 の反応式
[CH2:1]([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[C:11]([F:13])[C:10]([O:14]CC2C=CC=CC=2)=[C:9]([F:22])[CH:8]=1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([F:13])[C:10]([OH:14])=[C:9]([F:22])[CH:8]=1)[CH3:2]

参加物

4

反応物 1

HCID 90118234(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester

生成物 1

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

(E)-3-(4-Benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester (1.2 g, 3.77 mmol) obtained in Step C was dissolved in EtOH (20 mL), and 10% Pd/C (120 mg) was added to the solution. The mixture was stirred at room temperature under hydrogen atmosphere for 12 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.85 g, 98%).

後処理

  1. filtrationThe reactant was filtered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-04b6b1677efc443d9d11e4b92fcd26ee
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

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