Water → (6-Sec-butylsulfanyl-pyridin-2-yl)-methanol

HRID 62840ノート

反応式

HRID 62840 の反応式
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][CH:13]([CH2:15][CH3:16])[CH3:14])[N:7]=1)=O)C.[Li+].[BH4-].O>C1COCC1>[CH:13]([S:12][C:8]1[N:7]=[C:6]([CH2:4][OH:3])[CH:11]=[CH:10][CH:9]=1)([CH2:15][CH3:16])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 4148881Lithium borohydrideHCID 901182566-Sec-butylsulfanyl-pyridine-2-carboxylic acid ethyl ester

生成物 1

HCID 90118289(6-Sec-butylsulfanyl-pyridin-2-yl)-methanol収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

6-sec-Butylsulfanyl-pyridine-2-carboxylic acid ethyl ester (0.17 g, 0.71 mmol) obtained in Step A was dissolved in anhydrous THF (3 mL). 2.0 M LiBH4 solution (0.5 mL, 1.0 mmol) was added thereto, and the mixture was stirred at 40° C. for 1 hour. After the termination of the reaction, the reactant was cooled to room temperature. The reactant was added with water and then extracted with EtOAc. The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.126 g, 90%).

後処理

  1. customAfter the termination of the reaction
  2. temperaturethe reactant was cooled to room temperature
  3. extractionextracted with EtOAc
  4. customThe organic layer was separated
  5. dry with materialdried with MgSO4
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-0c405c0f80fc440a97b9ac682ac47e2a
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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