(E)-3-(4-benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester → HCID 22558806、化合物

HRID 62843ノート

反応式

HRID 62843 の反応式
[CH3:1][O:2][C:3](=[O:21])/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[C:8]([F:20])[CH:7]=1>CCOC(C)=O.CO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([F:20])[CH:7]=1

参加物

5

反応物 1

HCID 90118296(E)-3-(4-benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester

生成物 1

HCID 22558806HCID 22558806、化合物収率 105.1%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

(E)-3-(4-Benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester (0.37 g, 1.2 mmol) obtained in Step B was dissolved in EtOAc (4 mL) and MeOH (2 mL). The solution was added with 10% Pd/C (0.03 g), and the mixture was stirred under hydrogen atmosphere for 18 hours. The reactant was filtered by using celite, and the filtrate was washed with EtOAc to obtain the title compound (0.25 g, 98%).

後処理

  1. filtrationThe reactant was filtered
  2. washthe filtrate was washed with EtOAc

出典と根拠

ORDレコード
ord-55e6e12f805e47d785edb998192d92c3
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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