Triphosgene → 1-Difluoromethoxy-3-isocyanato-2-methylbenzene
反応式
[F:1][CH:2]([F:12])[O:3][C:4]1[C:5]([CH3:11])=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].Cl[C:14](Cl)([O:16]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[C:6]([N:7]=[C:14]=[O:16])[C:5]=1[CH3:11]参加物
4
実験手順
At room temperature, to a mixture of 3-difluoromethoxy-2-methylaniline 6.4 g and toluene 100 ml was added triphosgene 5.48 g, and the resulting mixture was stirred with heating under reflux for one hour. The reaction mixture was concentrated under reduced pressure to give 1-difluoromethoxy-3-isocyanato-2-methylbenzene 7.36 g.
後処理
- temperaturewith heating
- temperatureunder reflux for one hour
- concentrationThe reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-a40e5c5869b2438e8bd5aa4155140b81
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09314023B2
反応ノート
読み込み中…