Triphosgene → 1-Bromo-3-isocyanato-2-methyl-benzene

HRID 628499ノート

反応式

HRID 628499 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[CH3:9].Cl[C:11](Cl)([O:13]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]=[C:11]=[O:13])[C:3]=1[CH3:9]

参加物

4

反応物 2

HCID 94429TriphosgeneHCID 1235383-Bromo-o-toluidine

生成物 1

HCID 655423311-Bromo-3-isocyanato-2-methyl-benzene収率 106.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 1-bromo-2-methyl-3-aminobenzene 25.0 g, triphosgene 60.0 g and toluene 400 ml was stirred with heating under reflux for three hours. The reaction mixture after standing to cool was concentrated under reduced pressure to give 1-bromo-3-isocyanato-2-methylbenzene 30.3 g.

後処理

  1. temperaturewith heating
  2. temperatureunder reflux for three hours
  3. temperatureto cool
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5f6203d8a4e94671af14d4942d38cdf1
出典データセット
uspto-grants-2016_04
特許番号
US09314023B2

反応ノート

読み込み中…