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Potassium Carbonate → 1-{3-Bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one

HRID 628518
ノート
印刷プレビュー

反応式

HRID 628518 の反応式
Br[CH2:2][C:3]1[C:8]([Br:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]1.[CH3:17][C:18]1[CH:23]=[C:22]([N:24]2[C:28]([CH3:29])=[C:27]([CH3:30])[C:26]([CH3:31])=[N:25]2)[CH:21]=[CH:20][C:19]=1[OH:32].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:9][C:8]1[C:3]([CH2:2][O:32][C:19]2[CH:20]=[CH:21][C:22]([N:24]3[C:28]([CH3:29])=[C:27]([CH3:30])[C:26]([CH3:31])=[N:25]3)=[CH:23][C:18]=2[CH3:17])=[C:4]([N:10]2[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]2)[CH:5]=[CH:6][CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 898756621-(2-Bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazol-5-oneHCID 118236550Methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenol

生成物 1

HCID 1182365091-{3-Bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one収率 86.7%

試薬・触媒・溶媒 1

HCID 6342
Acetonitrile
溶媒

実験手順

A mixture of 1-(2-bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (described in Reference Preparation example 11) 3.1 g, 2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenol (described in Reference Preparation example 20) 1.6 g, potassium carbonate 1.3 g and acetonitrile 70 ml was stirred with heating under reflux for six hours, and the reaction mixture was then filtered and was concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography to give 1-{ 3-bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one 3.1 g.

後処理

  1. temperaturewith heating
  2. temperatureunder reflux for six hours
  3. filtrationthe reaction mixture was then filtered
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-28959d94acf241d6b9a41cf38fe91f95
出典データセット
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09314023B2

反応ノート

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