2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester

HRID 62858

反応式

HRID 62858 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N:6]=1)=[O:4].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:18][CH:19]([SH:21])[CH3:20]>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:21][CH:19]([CH3:20])[CH3:18])[N:6]=1)=[O:4]

参加物

5

反応物 3

HCID 63642-PropanethiolHCID 10796Cesium carbonateHCID 16217886Methyl 6-bromopyridine-2-carboxylate

生成物 1

HCID 901182976-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester収率 89.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).

後処理

  1. customAfter the termination of the reaction
  2. filtrationthe reactant was filtered
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-792a4140021c4e56b730b7d41a6c301c
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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