2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N:6]=1)=[O:4].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:18][CH:19]([SH:21])[CH3:20]>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:21][CH:19]([CH3:20])[CH3:18])[N:6]=1)=[O:4]参加物
5
実験手順
6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).
後処理
- customAfter the termination of the reaction
- filtrationthe reactant was filtered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-792a4140021c4e56b730b7d41a6c301c
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447044B2
反応ノート
読み込み中…