Water → (6-Isopropylsulfanyl-pyridin-2-yl)-methanol
反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][CH:12]([CH3:14])[CH3:13])[N:6]=1)=O.[Li+].[BH4-].O>C1COCC1>[CH:12]([S:11][C:7]1[N:6]=[C:5]([CH2:3][OH:2])[CH:10]=[CH:9][CH:8]=1)([CH3:14])[CH3:13]参加物
5
反応条件
- 温度
- 40 °C
実験手順
6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester (0.13 g, 0.61 mmol) obtained in Step A was dissolved in anhydrous THF (3 mL). 2.0M LiBH4 solution (0.5 mL, 1 mmol) was added thereto, and the mixture was stirred at 40° C. for 1 hour. After the termination of the reaction, the reactant was cooled to room temperature, added with water, and extracted with EtOAc. The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.08 g, 70%).
後処理
- customAfter the termination of the reaction
- temperaturethe reactant was cooled to room temperature
- extractionextracted with EtOAc
- customThe organic layer was separated
- dry with materialdried with MgSO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-23a03f644c474fe882bd4eaf80e0accb
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447044B2
反応ノート
読み込み中…