2-Propanethiol → 2-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

反応式

[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8](Cl)[N:7]=1)=[O:5])[CH3:2].[CH3:13][CH:14]([SH:16])[CH3:15]>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:16][CH:14]([CH3:15])[CH3:13])[N:7]=1)=[O:5])[CH3:2]

参加物

反応物 2

HCID 63642-Propanethiol

HCID 22509306Ethyl 2-chloropyrimidine-4-carboxylate

生成物 1

HCID 901183312-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester収率 68%

実験手順

2-Chloropyrimidine-4-carboxylic acid ethyl ester (0.024 g, 0.13 mmol) obtained in Step A and 2-propanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.02 g, 68%).

出典と根拠

ORDレコード: ord-bb76834c5a184a2880af0b5f4d64a1de
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447044B2

反応ノート

読み込み中…