Water → (2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol

HRID 62869

反応式

HRID 62869 の反応式
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH:13]([CH3:15])[CH3:14])[N:7]=1)=O)C.[BH4-].[Na+].O>CO>[CH:13]([S:12][C:8]1[N:7]=[C:6]([CH2:4][OH:3])[CH:11]=[CH:10][N:9]=1)([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 901183312-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

生成物 1

HCID 90118246(2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol収率 77.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After 2-isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester (0.1 g, 0.44 mmol) obtained in Step B was dissolved in MeOH (4 mL), NaBH4(0.033 g, 0.9 mmol) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was added with water, and then extracted with EtOAc. The separated organic layer was dried with MgSO4 and separated by column chromatography to obtain the title compound (0.063 g, 77%).

後処理

  1. customAfter the termination of the reaction
  2. extractionextracted with EtOAc
  3. dry with materialThe separated organic layer was dried with MgSO4
  4. customseparated by column chromatography

出典と根拠

ORDレコード
ord-b31d92927b9e4c29b9f49751a7272251
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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