Water → (2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol
反応式
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH:13]([CH3:15])[CH3:14])[N:7]=1)=O)C.[BH4-].[Na+].O>CO>[CH:13]([S:12][C:8]1[N:7]=[C:6]([CH2:4][OH:3])[CH:11]=[CH:10][N:9]=1)([CH3:15])[CH3:14]参加物
5
実験手順
After 2-isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester (0.1 g, 0.44 mmol) obtained in Step B was dissolved in MeOH (4 mL), NaBH4(0.033 g, 0.9 mmol) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was added with water, and then extracted with EtOAc. The separated organic layer was dried with MgSO4 and separated by column chromatography to obtain the title compound (0.063 g, 77%).
後処理
- customAfter the termination of the reaction
- extractionextracted with EtOAc
- dry with materialThe separated organic layer was dried with MgSO4
- customseparated by column chromatography
出典と根拠
- ORDレコード
- ord-b31d92927b9e4c29b9f49751a7272251
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447044B2
反応ノート
読み込み中…