Ethyl 3-(3-fluoro-4-methoxyphenyl)-2-methylprop-2-enoate → 3-(3-Fluoro-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:17])/[C:5](/[CH3:16])=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1)[CH3:2]参加物
4
実験手順
After (E)-3-(3-fluoro-4-methoxy-phenyl)-2-methyl-acrylic acid ethyl ester (0.728 g, 3.0 mmol) obtained in Step A was dissolved in EtOH (10 mL), 10% Pd/C (0.073 g) was added thereto, and the mixture was stirred at room temperature under hydrogen atmosphere for 12 hours. After the termination of the reaction, the reactant was filtered by using celite, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/2) to obtain the title compound (0.726 g, 98%).