Sodium Carbonate → 4-(4-Isopropylphenyl)pyridine

HRID 628832ノート

反応式

HRID 628832 の反応式
Cl.Br[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.[CH:9]([C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1)([CH3:11])[CH3:10].C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C.O>[CH:9]([C:12]1[CH:17]=[CH:16][C:15]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)=[CH:14][CH:13]=1)([CH3:11])[CH3:10]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 881004-Bromopyridinium chlorideHCID 27734804-Isopropylphenylboronic acid

生成物 1

HCID 229510894-(4-Isopropylphenyl)pyridine

試薬・触媒・溶媒 1

HCID 18373917Acetonitrile--water (1/1)溶媒

実験手順

Part A. A solution of 4-bromopyridine hydrochloride (1.0 g, 6.3 mmol) in acetonitrile-water (50 mL/20 mL) is treated with 4-isopropylbenzeneboronic acid (1.04 g, 6.3 mmol) and sodium carbonate (2.1 g, 25.2 mmol). The mixture is degassed twice, and a catalytic quantity of tetrakis(triphenylphosphine)palladium is added. The mixture is heated to reflux for 12 h., then cooled and poured into water (50 mL). The mixture is filtered and extracted with ethyl acetate (3×50 mL). The extracts are combined, washed with brine, dried over magnesium sulfate, filtered and evaporated to afford 1.01 g of sufficiently pure product, 4-(4-isopropyl-phenyl)-pyridine.

後処理

  1. customThe mixture is degassed twice
  2. additiona catalytic quantity of tetrakis(triphenylphosphine)palladium is added
  3. temperatureThe mixture is heated
  4. temperatureto reflux for 12 h.
  5. temperaturecooled
  6. additionpoured into water (50 mL)
  7. filtrationThe mixture is filtered
  8. extractionextracted with ethyl acetate (3×50 mL)
  9. washwashed with brine
  10. dry with materialdried over magnesium sulfate
  11. filtrationfiltered
  12. customevaporated

出典と根拠

ORDレコード
ord-9ccb15b898d346b8b3265b38e81e11f7
出典データセット
uspto-grants-2016_04
特許番号
US09315467B2

反応ノート

読み込み中…