3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide → 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide
反応式
[F:1][C:2]([F:18])([F:17])[CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[CH2:15][OH:16])=[O:5]>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]([F:17])([F:18])[CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[CH:15]=[O:16])=[O:5]参加物
4
実験手順
To a solution of 3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide (6.30 g, 23.9 mmol) in anhydrous CH2Cl2 (200 mL) was added MnO2 (20.0 g, 229 mmol). The mixture was refluxed for 16 hours. The mixture was filtered off and the filtrate was concentrated to give the desired product (5.30 g, yield 84%).
後処理
- temperatureThe mixture was refluxed for 16 hours
- filtrationThe mixture was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-c79b00c2c6c94766a6718edce9dbe914
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315462B2
反応ノート
読み込み中…