Sulfuric Acid → HCID 90118322、化合物

HRID 62895ノート

反応式

HRID 62895 の反応式
Cl[CH2:2][C:3]1[C:12]2[C:7](=[C:8]([F:15])[C:9]([OH:14])=[C:10]([F:13])[CH:11]=2)[O:6][C:5](=[O:16])[CH:4]=1.S(=O)(=O)(O)[OH:18]>[OH-].[Na+]>[F:13][C:10]1[C:9]([OH:14])=[C:8]([F:15])[C:7]2[O:6][CH:2]=[C:3]([CH2:4][C:5]([OH:16])=[O:18])[C:12]=2[CH:11]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 18757590HCID 18757590、化合物

生成物 1

HCID 90118322HCID 90118322、化合物

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

4-Chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone (0.2 g, 0.81 mmol) obtained in Step A was dissolved in 1N NaOH aqueous solution (8 mL), and the mixture was stirred under reflux for 2 hours. The reactant was acidified by the addition of sulfuric acid, and then extracted with EtOAc. The organic layer was dried with MgSO4, and distilled under reduced pressure to obtain the title compound (0.16 g).

後処理

  1. temperatureunder reflux for 2 hours
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried with MgSO4
  4. distillationdistilled under reduced pressure

出典と根拠

ORDレコード
ord-fa832b321433472cad9a2755ba052a0b
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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