関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Lithium borohydride | HCID 4148881 | — |
| 反応物 | Ethyl 2-(3-fluoro-4-methoxyphenyl)cyclopropanecarboxylate | HCID 58566289 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [2-(3-Fluoro-4-methoxy-phenyl)-cyclopropyl]-methanol | HCID 22347600 | 88.8% |
反応手順
After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid-ethyl ester (0.71 g, 2.98 mmol) was dissolved in anhydrous THF (10 mL), LiBH4-2.0M THF solution (3 mL, 5.96 mmol) was added thereto, and the mixture was stirred at 50° C. for 2 hours. After the termination of the reaction, the reactant was cooled to room temperature, added with water, and then extracted with EtOAc. The organic layer was separated, dried with MgSO4, and then concentrated under reduced pressure to obtain the title compound (0.519 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447044B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-991dbf733fd44ddbb49ee99f0828f5f2 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
