Water → [2-(3-Fluoro-4-methoxy-phenyl)-cyclopropyl]-methanol

HRID 62897ノート

反応式

HRID 62897 の反応式
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([F:17])[CH:10]=1)=O)C.[Li+].[BH4-].O>C1COCC1>[F:17][C:11]1[CH:10]=[C:9]([CH:7]2[CH2:8][CH:6]2[CH2:4][OH:3])[CH:14]=[CH:13][C:12]=1[O:15][CH3:16]

参加物

5

反応物 3

HCID 962WaterHCID 4148881Lithium borohydrideHCID 58566289Ethyl 2-(3-fluoro-4-methoxyphenyl)cyclopropanecarboxylate

生成物 1

HCID 22347600[2-(3-Fluoro-4-methoxy-phenyl)-cyclopropyl]-methanol収率 88.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid-ethyl ester (0.71 g, 2.98 mmol) was dissolved in anhydrous THF (10 mL), LiBH4-2.0M THF solution (3 mL, 5.96 mmol) was added thereto, and the mixture was stirred at 50° C. for 2 hours. After the termination of the reaction, the reactant was cooled to room temperature, added with water, and then extracted with EtOAc. The organic layer was separated, dried with MgSO4, and then concentrated under reduced pressure to obtain the title compound (0.519 g, 88%).

後処理

  1. customAfter the termination of the reaction
  2. temperaturethe reactant was cooled to room temperature
  3. extractionextracted with EtOAc
  4. customThe organic layer was separated
  5. dry with materialdried with MgSO4
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-991dbf733fd44ddbb49ee99f0828f5f2
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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