反应详情

温度

50 °C

After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid-ethyl ester (0.71 g, 2.98 mmol) was dissolved in anhydrous THF (10 mL), LiBH4-2.0M THF solution (3 mL, 5.96 mmol) was added thereto, and the mixture was stirred at 50° C. for 2 hours. After the termination of the reaction, the reactant was cooled to room temperature, added with water, and then extracted with EtOAc. The organic layer was separated, dried with MgSO4, and then concentrated under reduced pressure to obtain the title compound (0.519 g, 88%).

1. customAfter the termination of the reaction
2. temperaturethe reactant was cooled to room temperature
3. extractionextracted with EtOAc
4. customThe organic layer was separated
5. dry with materialdried with MgSO4
6. concentrationconcentrated under reduced pressure