Thionyl Chloride → 2-(3-Fluoro-4-methoxy-phenyl)-cyclopropanecarbonyl chloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:12][CH:11]2[C:13]([OH:15])=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O=S(Cl)[Cl:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:12][CH:11]2[C:13]([Cl:18])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]参加物
3
実験手順
After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid (0.848 g, 4.03 mmol) obtained in Step A was dissolved in anhydrous MC (10 mL), SOCl2 (3 mL, 40.34 mmol) was added thereto, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure to obtain the title compound, which was used in the next step without a separate purification process
後処理
- additionwas added
- customAfter the termination of the reaction
- concentrationthe reactant was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9cd02290e85548a5a128b7969d4c6865
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447044B2
反応ノート
読み込み中…