Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoate → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl ester

HRID 62922

反応式

HRID 62922 の反応式
Cl[CH2:2][C:3]1[C:4]([S:9][CH:10]([CH3:12])[CH3:11])=[N:5][CH:6]=[CH:7][CH:8]=1.[CH2:13]([O:15][C:16](=[O:27])[CH:17]([CH3:26])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:27])[CH:17]([CH3:26])[CH2:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:2][C:3]2[C:4]([S:9][CH:10]([CH3:12])[CH3:11])=[N:5][CH:6]=[CH:7][CH:8]=2)=[CH:23][CH:24]=1)[CH3:14]

参加物

3

反応物 2

HCID 20748401Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoateHCID 538166813-Chloromethyl-2-isopropylsulfanyl-pyridine

生成物 1

HCID 901182013-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl ester収率 53.5%

実験手順

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.063 g, 0.31 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (0.065 g, 0.31 mmol) obtained in Step B of Preparation Example 3 were reacted in the same manner as in Step A of Example 1 to obtain the title compound (0.062 g, 53%).

後処理

  1. customwere reacted in the same manner as in Step A of Example 1

出典と根拠

ORDレコード
ord-5bf84665a5bb4ea2846f25921390c4cc
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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