Water → Methyl 5-bromo-3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

HRID 629357ノート

反応式

HRID 629357 の反応式
[Cl:1][C:2]1[C:3]([OH:16])=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[C:5]([O:7][CH3:8])=[O:6].[Br:17]N1C(=O)CCC1=O.O>CN(C=O)C>[Br:17][C:10]1[C:11]([C:12]([F:14])([F:15])[F:13])=[C:2]([Cl:1])[C:3]([OH:16])=[C:4]([CH:9]=1)[C:5]([O:7][CH3:8])=[O:6]

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 118468129Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

生成物 1

HCID 118468280Methyl 5-bromo-3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate収率 84.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
15 °C

実験手順

To a solution of methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate (6.30 g) in DMF (65.0 mL) was added N-bromosuccinimide (4.41 g), and the mixture was stirred at 15° C. for 16 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (7.00 g).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e3f3c47a277c43b4bc0cbd5465f0b5c0
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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