Sulfuric acid magnesium salt (1:1) → 1,5-anhydro-2,4-dideoxy-2-(6-(4-methoxybenzyl)-4,5-dimethyl-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-L-threo-pentitol

To a solution of methyl 2-formyl-5-(4-methoxybenzyl)-3,4-dimethylbenzoate (0.10 g) in THF (1.90 mL) were added (3S,4S)-3-aminotetrahydro-2H-pyran-4-ol (0.04 g) and anhydrous magnesium sulfate (0.07 g), and the mixture was stirred at room temperature for 5 hr. The insoluble substance was removed by filtration, and the filtrate was concentrated. The residue was diluted with methanol (1.90 mL)-THF (1.90 mL), sodium triacetoxyborohydride (0.13 g) was added thereto, and the mixture was stirred at room temperature for 2.5 days. The reaction mixture was diluted with ethyl acetate, and the mixture was washed with water and saturated brine. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.04 g).

1. customThe insoluble substance was removed by filtration
2. concentrationthe filtrate was concentrated
3. additionThe residue was diluted with methanol (1.90 mL)-THF (1.90 mL), sodium triacetoxyborohydride (0.13 g)
4. additionwas added
5. stirringthe mixture was stirred at room temperature for 2.5 days
6. additionThe reaction mixture was diluted with ethyl acetate
7. washthe mixture was washed with water and saturated brine
8. concentrationThe organic layer was concentrated under reduced pressure
9. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

ORDレコード

ord-f9a1b7dc14d4476fa5f6a66b9371f166

出典データセット

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09315458B2