N-bromobutanimide → 5-Bromo-3-fluoro-2-hydroxy-4-methoxybenzoic acid

HRID 629479ノート

反応式

HRID 629479 の反応式
[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].C1C(=O)N([Br:21])C(=O)C1>CN(C=O)C>[Br:21][C:9]1[C:10]([O:11][CH3:12])=[C:2]([F:1])[C:3]([OH:13])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 847699353-Fluoro-2-hydroxy-4-methoxybenzoic acid

生成物 1

HCID 848075045-Bromo-3-fluoro-2-hydroxy-4-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
25 °C

実験手順

To a solution of 3-fluoro-2-hydroxy-4-methoxybenzoic acid (7.30 g) in DMF (70.0 mL) was added NBS, and the mixture was stirred at 25° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate. The mixture was washed with water and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (8.86 g).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. additionthe residue was diluted with ethyl acetate
  3. washThe mixture was washed with water and saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-5d0f347f800e4cba9730170a4ddecd97
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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