Water → (1-ethyl-4-methyl-1H-imidazol-5-yl)methanol
反応式
[CH2:1]([N:3]1[C:7]([CH:8]=[O:9])=[C:6]([CH3:10])[N:5]=[CH:4]1)[CH3:2].[BH4-].[Na+].O>CO>[CH2:1]([N:3]1[C:7]([CH2:8][OH:9])=[C:6]([CH3:10])[N:5]=[CH:4]1)[CH3:2]参加物
5
実験手順
To a 0° C. solution of 1-ethyl-4-methyl-1H-imidazole-5-carbaldehyde (806 mg, 5.8 mmol) in anhydrous methanol (55 mL) was added sodium borohydride (500 mg, 13.2 mmol). The reaction mixture was stirred at room temperature overnight. Water (30 mL) was added. The mixture was evaporated. The resultant residue was treated with EtOAc (50 mL). The solution was dried over MgSO4, filtered, evaporated, and dried in vacuo, affording (1-ethyl-4-methyl-1H-imidazol-5-yl)methanol (754 mg, 93% yield). The product was used without further purification.
後処理
- customThe mixture was evaporated
- additionThe resultant residue was treated with EtOAc (50 mL)
- dry with materialThe solution was dried over MgSO4
- filtrationfiltered
- customevaporated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-76027da78de44fdfa7c7f28522ccce54
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315521B2
反応ノート
読み込み中…