Chloride → N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

HRID 630412ノート

反応式

HRID 630412 の反応式
[Cl-].C(CC(CC)(NC(C)C)C)C.[Si:13]([O:20][CH2:21][C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[C:24](Cl)[CH:23]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[Si:13]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[CH:26][C:27]=1[O:28][CH3:29])([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:14])[CH3:15]

参加物

4

反応物 3

HCID 312ChlorideHCID 67145019N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-acrylamideHCID 129867302Diethyldiisopropylamine

生成物 1

HCID 67469526N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

実験手順

Obtained as a solid (63%) from [4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]amine (intermediate 99; 5 g, 18.7 mmol), acryloil chloride (1.98 mL, 24.28 mmol) and diethyldiisopropylamine (4.9 mL, 28.06 mmol) following the experimental procedure as described in intermediate 40. The crude obtained was purified by column chromatography with silica gel, eluting with methylene chloride.

後処理

  1. customThe crude obtained
  2. customwas purified by column chromatography with silica gel
  3. washeluting with methylene chloride

出典と根拠

ORDレコード
ord-cdbbf9f8ce6f4afcaeb5d1ad7d278e1e
出典データセット
uspto-grants-2016_04
特許番号
US09315463B2

反応ノート

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