Hydrazine → 4-Hydrazinylpyridin-2(1H)-one

HRID 631653ノート

反応式

HRID 631653 の反応式
[NH2:1][NH2:2].O[C:4]1[C:5]([OH:10])=[N:6][CH:7]=[CH:8][CH:9]=1>COCCOC>[NH:1]([C:9]1[CH:8]=[CH:7][NH:6][C:5](=[O:10])[CH:4]=1)[NH2:2]

参加物

4

反応物 2

HCID 9321HydrazineHCID 178516237HCID 178516237、化合物

生成物 1

HCID 136108294-Hydrazinylpyridin-2(1H)-one収率 78%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

To a solution of hydrazine (8 mL) in DME (40 mL) was added dihydroxypyridine (2.00 g, 18 mmol) and the reaction heated at reflux overnight. The solution was cooled to rt, and the solids removed by filtration. The filtrate was concentrated and the resulting solid crystallized from hot EtOH to afford 4-hydrazinylpyridin-2(1H)-one (1.75 g, 78% yield). LC-MS (ESI) m/z 126 (M+H)+.

後処理

  1. temperaturethe reaction heated
  2. temperatureat reflux overnight
  3. customthe solids removed by filtration
  4. concentrationThe filtrate was concentrated
  5. customthe resulting solid crystallized from hot EtOH

出典と根拠

ORDレコード
ord-7237a71d73034ee9ab2ff86d01f650e4
出典データセット
uspto-grants-2016_04
特許番号
US09320739B2

反応ノート

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