4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

HRID 6318

反応式

HRID 6318 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][CH:12]([CH2:15][CH3:16])[CH2:13]O.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH:12]([CH3:13])[CH2:15][CH3:16])=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 87232-Methyl-1-butanol

生成物 1

HCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester収率 83%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4.0 g of p-hydroxybenzoic acid and 12.5 g of (-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while removing the generated water out from the reaction system. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. The reaction solution was then dried and concentrated, and the concentrate was purified by column chromatography, to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =4.9° (CHCl3)). (Yield: 83%)

後処理

  1. customwhile removing the generated water out from the reaction system
  2. washSubsequently, the reaction solution was washed with water
  3. customto remove sulfuric acid out
  4. customThe reaction solution was then dried
  5. concentrationconcentrated
  6. customthe concentrate was purified by column chromatography

出典と根拠

ORDレコード
ord-b4a0964d88644cb69fc49099e36ac464
出典データセット
uspto-grants-1993_09
特許番号
US05248446

関連ノート

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