N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide → HCID 178425663、化合物

HRID 631869ノート

反応式

HRID 631869 の反応式
C([N:8]1[C:12]([C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[NH:20][S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])=[N:11][N:10]=[N:9]1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:19][C:18]1[C:13]([C:12]2[NH:8][N:9]=[N:10][N:11]=2)=[C:14]([NH:20][S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH:15]=[CH:16][CH:17]=1

参加物

5

反応物 2

HCID 68296407N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide2 回HCID 178418361HCID 178418361、化合物

生成物 1

HCID 178425663HCID 178425663、化合物収率 205.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide (Intermediate 15, 0.05 g) was dissolved in ethyl acetate (10 mL) under a nitrogen atmosphere. Palladium on carbon (10%, 0.02 g) was added and the nitrogen atmosphere was replaced by hydrogen. The mixture was stirred for 7 days and then filtered through celite and the solvent was removed by evaporation under vacuum. The residue was purified by preparative HPLC (C18). The fractions containing the desired product were combined, and the solvent was removed by evaporation to give the title compound as a white solid (0.08 g).

後処理

  1. filtrationfiltered through celite
  2. customthe solvent was removed by evaporation under vacuum
  3. customThe residue was purified by preparative HPLC (C18)
  4. additionThe fractions containing the desired product
  5. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-7a9862ae3bd248a8bc9dcdde75e4bf02
出典データセット
uspto-grants-2016_04
特許番号
US09321740B2

反応ノート

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