Benzenesulfonyl chloride → HCID 68296414、化合物

HRID 631873ノート

反応式

HRID 631873 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[NH2:15])=[O:4].[C:16]1([S:22](Cl)(=[O:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>N1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[NH:15][S:22]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:24])=[O:23])=[O:4]

参加物

4

反応物 2

HCID 7369Benzenesulfonyl chlorideHCID 11521576Methyl 2-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylate2 回

生成物 1

HCID 68296414HCID 68296414、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 2-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (Intermediate 5, 1.5 g) in pyridine (20 mL) was added benzenesulfonyl chloride (0.95 mL). The mixture was stirred for 1 hour then concentrated under vacuum. The residue was dissolved in ethyl acetate and washed with 1N hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was evaporated under vacuum to give the title compound as an off-white crystalline solid (2.4 g).

後処理

  1. concentrationthen concentrated under vacuum
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with 1N hydrochloric acid
  4. dry with materialdried with magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated under vacuum

出典と根拠

ORDレコード
ord-48cb155985cd49dc9c4d21d645420729
出典データセット
uspto-grants-2016_04
特許番号
US09321740B2

反応ノート

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