反応式
[C:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>C(O)C.[Pd]>[CH:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
4
実験手順
To a solution of 6-cyclohexenyl-pyridine-2-carboxylic acid (0.8 g, 3.94 mmol) in ethanol (50 mL) was added 10% palladium on carbon (20%, 0.16 g) under an atmosphere of nitrogen. The suspension was degassed under vacuum and exchanged with hydrogen several times. The mixture was stirred under hydrogen balloon at ambient temperature overnight. The reaction mixture was filtered through a pad of celite, the pad was washed with ethanol and the combined filtrates were concentrated to dryness. The crude title compound (0.62 g, green oil) was used for the next reaction step without further purification; MS (EI): m/e 206.2 [M+H]+
後処理
- customThe suspension was degassed under vacuum
- filtrationThe reaction mixture was filtered through a pad of celite
- washthe pad was washed with ethanol
- concentrationthe combined filtrates were concentrated to dryness
- customThe crude title compound (0.62 g, green oil) was used for the next reaction step without further purification
出典と根拠
- ORDレコード
- ord-2bf48c0b49b441d7ad41efd56c64c5ab
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321727B2
関連ノート
読み込み中…