6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid → 6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 632081

反応式

HRID 632081 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH:17]2[CH2:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[NH2:20][C:21]([CH2:28][CH3:29])([CH2:26][CH3:27])[C:22]([NH:24][CH3:25])=[O:23]>>[CH2:26]([C:21]([NH:20][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH:17]2[CH2:19][CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:22](=[O:23])[NH:24][CH3:25])[CH2:28][CH3:29])[CH3:27]

参加物

3

反応物 2

HCID 710874536-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acidHCID 798103702-Amino-2-ethyl-N-methyl-butyramide

生成物 1

HCID 711131786-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (Example 48 e) and 2-amino-2-ethyl-N-methyl-butyramide (Example 70 b) as starting materials, MS (EI): m/e=400.2 [M+H]+.

出典と根拠

ORDレコード
ord-0c8390ad788b41169acb81e8718fcf4e
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

関連ノート

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