(2S)-2-amino-N,4,4-trimethyl-pentanamide → 6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

HRID 632290

反応式

HRID 632290 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12](O)=[O:13])[CH:9]=[CH:8][C:7]=2[N:15]2[C:18]3([CH2:21][O:20][CH2:19]3)[CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[NH2:22][C@@H:23]([CH2:28][C:29]([CH3:32])([CH3:31])[CH3:30])[C:24]([NH:26][CH3:27])=[O:25]>>[CH3:30][C:29]([CH3:32])([CH3:31])[CH2:28][C@H:23]([NH:22][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[C:18]3([CH2:21][O:20][CH2:19]3)[CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:13])[C:24](=[O:25])[NH:26][CH3:27]

参加物

3

反応物 2

HCID 57635521(2S)-2-amino-N,4,4-trimethyl-pentanamideHCID 710877046-(Cyclopropylmethoxy)-5-(6-oxa-1-azaspiro[3.3]heptan-1-yl)picolinic acid

生成物 1

HCID 711130556-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-(cyclopropylmethoxy)-5-(6-oxa-1-azaspiro[3.3]heptan-1-yl)picolinic acid and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials. MS (EI): m/e=431.1 [M+H]+.

出典と根拠

ORDレコード
ord-c285b028ec5245af96abe8fe4a1b0644
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

関連ノート

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