Lithium Hydroxide → (S)-2-{[5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carbonyl]-amino}-4-methyl-pentanoic acid

反応式

[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:20][C@@H:21]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:22]([O:24]CC)=[O:23])=[O:19])=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.[OH-].[Li+]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:20][C@@H:21]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:22]([OH:24])=[O:23])=[O:19])=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1

参加物

反応物 2

HCID 3939Lithium Hydroxide

HCID 86674796(S)-Ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-4-methylpentanoate

生成物 1

HCID 71087637(S)-2-{[5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carbonyl]-amino}-4-methyl-pentanoic acid

実験手順

In analogy to the procedure described in Example 5 c), (S)-ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-4-methylpentanoate was saponified with lithium hydroxide to obtain the title compound. MS (EI): m/e=385.2 [M+H]+.

出典と根拠

ORDレコード: ord-97be0e705218483f82984dca2ea58ebb
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09321727B2

反応ノート

読み込み中…