[2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol → 2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]benzaldehyde

HRID 632507

反応式

HRID 632507 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:6]=[CH:5][C:4]=1[CH2:17][OH:18]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:6]=[CH:5][C:4]=1[CH:17]=[O:18]

参加物

4

反応物 1

HCID 117888927[2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol

生成物 1

HCID 897259352-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]benzaldehyde収率 99%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

反応条件

温度
55 °C

実験手順

To 220 mL of a solution of 22.2 g of [2-methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol in CHCl3 was added 61.8 g of manganese dioxide, and the mixture was stirred at 55° C. for 13 hours. The reaction mixture was allowed to stand to cool. After insoluble matter was filtered off, the mother liquor was concentrated to give 21.8 g of the title compound (99% yield).

後処理

  1. temperatureto cool
  2. filtrationAfter insoluble matter was filtered off
  3. concentrationthe mother liquor was concentrated

出典と根拠

ORDレコード
ord-976cd24524544abd984e681c5980a3aa
出典データセット
uspto-grants-2016_04
特許番号
US09321752B2

関連ノート

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