Triethylamine → N-(4-bromo-1-methyl-1H-pyrazol-3-yl)-4-chlorobutanamide

HRID 632765ノート

反応式

HRID 632765 の反応式
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][N:5]([CH3:7])[CH:6]=1.C(N(CC)CC)C.[Cl:16][CH2:17][CH2:18][CH2:19][C:20](Cl)=[O:21].[Cl-].[NH4+]>C1COCC1>[Br:1][C:2]1[C:3]([NH:8][C:20](=[O:21])[CH2:19][CH2:18][CH2:17][Cl:16])=[N:4][N:5]([CH3:7])[CH:6]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 783704-Chlorobutyryl chlorideHCID 27352834-bromo-1-methyl-1H-pyrazol-3-amine

生成物 1

HCID 118061399N-(4-bromo-1-methyl-1H-pyrazol-3-yl)-4-chlorobutanamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (310 mg) and triethylamine (0.37 mL) in THF (8.8 mL) was added 4-chlorobutanoyl chloride (0.22 mL) under ice-cooling, and the mixture was stirred at 0° C. for 30 min. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (456 mg).

後処理

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-1d3631e8debd4ebaa2d974ef803fcf94
出典データセット
uspto-grants-2016_04
特許番号
US09321757B2

反応ノート

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