化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 5-Ethynyl-6-methylpyridin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine | HCID 59255232 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Ethynyl-6-methylpyridin-2-amine | HCID 55285938 | — |
反応手順
The title compound is synthesized according to general procedure GP3 starting from 4.3 g (21.0 mmol) 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.5 g (10.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 3.6 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321771B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-16c6e01370e84b478d5fa4798cefb8ab |
| 出典メモ | uspto-grants-2016_04 |