化工社化工社 化学情報印刷レポート · 研究参考用
Ethylamine → [5-(4-Chloro-6-ethyl-pyrimidin-5-ylethynyl)-pyridin-2-yl]-ethyl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylamine | HCID 6341 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Chloro-6-ethyl-5-iodopyrimidine | HCID 10978487 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 生成物 | [5-(4-Chloro-6-ethyl-pyrimidin-5-ylethynyl)-pyridin-2-yl]-ethyl-amine | HCID 86661576 | — |
反応手順
The title compound is synthesized according to general procedure GP2 starting from 4-chloro-6-ethyl-5-iodo-pyrimidine using 5-Ethynyl-pyridin-2-yl)-ethyl-amine (A-28), CuI, bis-(triphenyl-phoshine)palladium(II) chloride, triethylamine in THF. After work-up the desired compound is obtained in good yield and acceptable purity.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321771B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-47f74410b7e7435a843fe968c0b1a6bb |
| 出典メモ | uspto-grants-2016_04 |