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HRID632898

反应详情

EQUATION

反应方程式

HRID 632898 的结构方程式

REACTANTS

反应物

4
结构：CCN
HCID6341

Ethanamine

C2H7N

结构：C1CCOC1
HCID8028

Tetrahydrofuran

C4H8O

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCc1ncnc(Cl)c1I
HCID10978487

4-Chloro-6-ethyl-5-iodopyrimidine

C6H6ClIN2

PRODUCTS

生成物

1
结构：CCNc1ccc(C#Cc2c(Cl)ncnc2CC)cn1
HCID86661576

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1
催化剂HCID178418476

未命名化合物

PROCEDURE

实验过程

The title compound is synthesized according to general procedure GP2 starting from 4-chloro-6-ethyl-5-iodo-pyrimidine using 5-Ethynyl-pyridin-2-yl)-ethyl-amine (A-28), CuI, bis-(triphenyl-phoshine)palladium(II) chloride, triethylamine in THF. After work-up the desired compound is obtained in good yield and acceptable purity.

WORKUP

后处理

  1. customThe title compound is synthesized