2,2,4-trimethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one → 6-amino-2,2,4-trimethyl-2H-1,4-benzoxazine-3(4H)-one
反応式
[CH3:1][C:2]1([CH3:17])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=[CH:13][C:4]=2[O:3]1>CO.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:4]2[O:3][C:2]([CH3:1])([CH3:17])[C:7](=[O:8])[N:6]([CH3:9])[C:5]=2[CH:10]=1参加物
4
実験手順
A mixture of 2,2,4-trimethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (290 mg, 1.23 mmol, 1 equiv.) in 10 mL of MeOH in the presence of 29 mg of Pd/C was hydrogenated at room temperature for 3 h. The reaction mixture was then filtered through a pad of celite and the filtrate was concentrated to give 240 mg (Yield=95%) of product as a pale brown solid which was used in the next step without further purification.
後処理
- filtrationThe reaction mixture was then filtered through a pad of celite
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d280986bc450498589d9beefe09e5342
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321763B2
反応ノート
読み込み中…